Arc 1: The Lizard
- An angry scientist plans to take revenge on Norman Osborn by becoming the Vulture. Peter tries to get a job at the Bugle. The Enforcers are hired.
- Max Dillon becomes Electro and hates the idea of not living a normal life, Peter tries to get Liz Allen to warm up to him.
- Connors uses his Lizard DNA formula, Peter stops him, but the photo gets him kicked out of the lab, and out of a few friendships
Arc 2: The Big Man
- Montana becomes the Shocker, hoping to defeat Spider-Man, while Peter ditches out on Harry, causing problems.
- Peter makes up with his friends, and he and Harry try our for football, but he also has to deal with Sandman. Liz Allen hints a liking toward Peter.
- With Sandman down, Rhino takes his turn, Spider-Man then realizes this was all a big job, creating supervillains. He approaches the Big Man, who easily defeats him. Peter is turned down by Betty, but meets Mary Jane Watson.
Arc 3: The Green Goblin
- The Green Goblin terrorizes the Big Man at a party where Jameson is. Mary Jane is introduced to the clan. Harry is taking Globulin Green
- Doc Ock's arms are attached to Otto, thanks to Goblin. Harry begins to black out. Flash and Liz break up.
- During Halloween, Spider-Man tries to find the identity of the Goblin, but is it who he assumes? John Jameson lands safely on Earth.
Arc 4: The Symbiote
- Spider-Man and Black Cat fight over the alien, which ends up attaching to Peter, she then helps him take down his imposter, Chameleon
11. Group Therapy
- Doc Ock creates the Sinister Six to destroy Spider-Man, but the Black Suit is too much for them.
- Peter realizes the suit is taking over so he gets rid of it, unknowingly, it attaches to an angry Eddie Brock, who then becomes Venom
- Peter fights Venom on Thanksgiving, and then save Gwen, who later confesses her love to Peter.