The name Spider-Man 2099 may pertain to any of the following:
- Miguel O'Hara - The original Spider-Man of the year 2099 who fights against the oppressive tyranny of the Alchemax corporation.
- Miguel O'Hara - Joined the Exiles team and reality hopped until he found an alternate version of Mary Jane and fell in love with her. Killed by Morlun in the Spider-Verse event.
- Miguel O'Hara - Teenage version of Miguel, who got powers from a Timestorm. He was combat trained by Human Torch 2099. Killed in the Spider-Verse event by Morlun.
- Miguel O'Hara - History is unknown.
- Piguel O'Malley - Talking pig version of Miguel O'Hara.
- Mig-El Gand - An amalgamation of Miguel O'Hara and DC Comics' Mon-El.
- Miguel O'Hara - This version of Miguel was greeted by a version of Peter Parker chasing Norman Osborn. He wanted to give up being Spider-Man, but after some kind words from Peter, he decided to continue.
- Miguel O'Hara - In this reality, the possible future of 2099 was changed when Peter Parker died at the hands of Eddie Brock as Anti-Venom. Miguel went back in time to save Peter and fix any mistakes done to reality.