The Black Cat, the former lover of Spider-Man, returns to New York City to help him.
What's New Pussy Cat? (Issue #1)
Spider-Man is looking for a missing woman named Tricia and investigating the death of Donald Phillips, an honor roll student who died from a heroin overdose, despite a lack of evidence that he had ever used heroin. Spider-Man confronts a drug dealer, and learns of Mr. Brownstone (a name that is itself a slang term for heroin), who is rumoured to molest teenaged boys, and a lackey, Hunter Todd.
The Black Cat, also looking for Tricia, meets up with Spider-Man. The two confront Hunter, whose girlfriend dies of a drug overdose. At the same moment, Mr. Brownstone is revealed as a concert violinist named Garrison Klum.
A Ruse By Any Other Name... (Issue #2)
Klum turns off a cell phone and enters a stage at Carnegie Hall. Spider-Man and Black Cat crash a party being held there as they confront and defeat the villain 'Scorpia'. While Klum mugs for the camera, Spider-Man begins to suspect he is Mr. Brownstone. A man named 'Pavan' is revealed to be working for Spider-Man.
Hate Crimes (Issue #3)
Spider-Man and Black Cat learn that Scorpia was hired by Alberto Ortega, the head of a local drug syndicate, to assassinate Klum. Klum kills the Ortega gang via heroin overdoses. Black Cat leaves Spider-Man after a disagreement on how to handle the case. When she confronts Klum herself, it is revealed that he was a mutant as he uses his powers to teleport a small quantity of heroin directly into her heart. He then starts cutting open her costume with the intention of raping her.
A Study in Scarlet (Issue #4)
Felicia Hardy waits in prison at Riker's Island, accused of Klum's murder. Matt Murdock, also known as Daredevil, tries to convince Felicia to undergo a rape kit; if she had been raped, Klum's death would be ruled as self-defense but Felicia denies being raped. Spider-Man and Daredevil decide to break Felicia out of prison. Francis Klum, Garrison Klum's lackey and younger brother, has already done so. He forces Daredevil and Spider-Man to fight, then teleports away with Felicia, leaving Daredevil and Spider-Man dazed.
Trickle Down (Issue #5)
Spider-Man and Daredevil decide to contact Nightcrawler of the X-Men, since he possesses similar teleportation powers as Klum. Francis, elsewhere, explains his past to Felicia.
Over the years, Francis was sexually abused by his older brother, who used him and his own talents to gain power. Garrison's main focus was to deliver drugs into his client, who paid heavily for no needle tracks. Francis had killed Garrison by teleporting inside his body and blowing him up out from the inside out in order to save Felicia. In attempting to persuade Francis to turn himself in, Felicia reveals she too had once been raped.
One in Four (Issue #6)
Flashbacks reveal that Felicia was raped by her boyfriend, Ryan, as a freshman at Empire State University.She does not report the rape, not wanting to become "just another statistic," and trains in fighting techniques, intent on revenge on her attacker. Ryan dies in a car accident before she could do anything, however. The story nearly convinces Francis, but Spider-Man and Daredevil show up at an inopportune moment, and a fight erupts. Francis falls from a great height but teleports away before hitting the water. Later, a disfigured Francis swears his revenge on Spider-Man as well as Black Cat, enlisting the aid of The Kingpin, who sells him the suit formerly worn by Mysterio.
- The title of the comic book series is an nod to William Shakespeare's Julius Caesar. In the play, Mark Antony says, with regards to Caesar, "The evil that men do lives after them; The good is oft interred with their bones."