The name Madame Web may pertain to any of the following:
- Cassandra Webb - the original Madame Web.
- Julia Carpenter - the second and current Madame Web.
- Madame Web - a women obsessed with Spider-Man.
- Cassandra Webb - a psych who attempted to alter Spider-Woman's memories.
- Cassandra Web - a clairvoyant who inspired an entire temple of prophetic acolytes.
- Cassandra Webb - an agent of S.H.I.E.L.D. who trains young telepaths.
- Cassandra Webb - Spider-Girls' mentor and teacher.
- Cassandra Webb - a cosmic being who trained Spider-Man to fight Spider-Carnage.