|Deadpool Kills the Marvel Universe|
|Debut appearance:||Deadpool Kills the Marvel Universe #1|
|Cullen Bunn, Dalibor Talajic|
|Deadpool Kills the Marvel Universe Vol 1|
|Inhabitants:||Spider-Man, Mary Jane Watson, May Parker, Shocker|
Earth-12101 is an alternate reality where an alternate version of Deadpool started hearing voices in his head that made him want to kill every superhero and supervillain he could find.
Deadpool is committed to the Ravencroft Asylum by the X-Men. They believe that it may heal him from his insanity. However, the doctor is actually Psycho-Man, and tries to brainwash Deadpool into doing his bidding.
He wanted to do this by getting rid of his inner voices, however, his plan went wrong when Deadpool's original voices are replaced by a new one that wanted nothing but death, and told Deadpool to kill everyone. After killing Psycho-Man and blows up the Asylum, he kills the Fantastic Four and takes a device from a dead Reed Richards to find a version of Uatu the Watcher and kills him by cutting his head off.
After killing a version of Doctor Doom, Ghost Rider and Howard the Duck, he goes after Spider-Man. After a wild chase in the city, Spider-Man mocks Wade about how he isn't funny, and why none of his villains came to kill him. After a long stalling from Spider-Man's question, and when Spider-Man has Deadpool in his hands, Deadpool kills him Peter by shooting him from the bottom from his head a with a single bullet from a pistol.