|The Last Gun On Earth|
|Debut appearance:||Marvel Universe Vs. The Punisher #1|
|Marvel Universe Vs. The Punisher Vol 1|
|Inhabitants:||Patient Zero, Mary Jane, Doctor Octopus|
Earth-11080 is an alternate reality where a diaease has spread throughout earth, which turns all superheroes into cannibals, except for the Punisher, who is the only immune human on earth, making him capable of stopping the diaease.
After a plague goes off, Punisher plans to kill every single hero on Earth to save the rest of humanity.
Spider-Man is killed among the infected superheroes.